Abstract
Melatonin in a daily dose of 50 μg/rat facilitated the extinction of active avoidance reflex and decreased the intertrial activity during extinction. However, it had no effect on learning and intertrial activity during acquisition. Pinealectomy was ineffective on acquisition, extinction and intertrial activity. Melatonin (100 μg/rat) given in 2 consecutive days facilitated the passive avoidance behavior in water deprived animals in two different experimental situations. Fifty μg of melatonin or pinealectomy was without effect on passive avoidance behavior. Neither melatonin nor pinealectomy had any influence on water intake or on exploratory activity.
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