Abstract
Background: Polymer gels beam sensitive are valuable and confident for measurement of 3D dose distributions. One of the special features of this type of dosimeters is their tissue equivalence, which makes them appropriate for the investigation of dose enhancement with contrast agents with high atomic number. Objective: The purpose of this study is an investigating of dose enhancement dependent in energy within the gel medium with used of conformal distribution gold nanoparticle as contrast agents by high atomic number material. Methods: In this work, gold nanoparticles (GNPs) of 50nm diameter with 0.1m concentration embedded in gel and irradiated by different megavoltage energy of 18MVand 6MV photon beam. Then GN- MAGICA and MAGICA dose response curves compare and achieved dose enhancement. Results: Experimental results have shown dose enhancement factor of 6MV and 18MV in 0.1mM, concentration is 1.74 and 1.04 respectively. Conclusion: The results showed that by adding of gold nanoparticles to the MAGICA polymer gel absorbed dose is increased. The levels of polymerization of irradiated gels with and without AuNPs in energy 6MV is more than energy 18MV. It seems that because of the dominance of photoelectric effect at low energies and pair production effect at high energies.
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