Abstract
The objective of this study was to determine the effect of some drugs on body weight, potassium and sodium concentration of female rabbits. A randomized complete block design with three replicates was used, the treatments consisted of 3 drugs of dexamethasone, cyperoheptadine and the combination of dexamethasone and cyperoheptadine administered orally with doses of 0.9 mg/kg of body weight with drugs two times a day for 45 days. Body weight and the concentration of sodium and potassium were measured. The results showed that body weight and the concentration of sodium and potassium significantly affected with treatments. The cyperoheptadine of this drugs increased body weight from (910 at zero time to 1693 g at the end of experimental period), where the increments found to be out of the normal range (16 g). It was found that potassium concentration decreased with time and the final values were (2.20 mg/dl), (2.60 mg/dl), (3.20 mg/dl) for dexamethasone, the combination and cyperoheptadine, respectively. No significant differences between these values found and they were below the normal range of potassium concentration (4.0–6.5 mg/dl). According to the results found the study concluded that cyperoheptadine and the combination increased body weight. All drugs decreased potassium concentration. Physician and pharmacist should be consultant before using these drugs to avoid the adverse effects is needed as recommended point of view, effects of drugs on serum total cholesterol, triglyceride, high-density lipoprotein, low density lipoprotein and very low density lipoprotein are also recommended for future work.
Highlights
The causes of weight gain were not known exactly due to some interaction between drugs and medications roles in this position
One of the most drugs misused by Sudanese women for body weight gain is dexamethasone are tablets for oral administration has many uses in the treatment of cancer
With respect to comparison between groups, after 7 days of application of the treatments, no significant (p≤0.05) differences were found in weight between dexamethasone, cyperoheptadine, the combination of dexamethasone with cyperoheptadine and the control
Summary
The causes of weight gain were not known exactly due to some interaction between drugs and medications roles in this position. Because some medications can increase appetite, by causing fluid retention, or slowly lead to weight gain during a period of applications or due to fatigue and lower activity that cause weight gain. One of the most drugs misused by Sudanese women for body weight gain is dexamethasone (locally knows as Alnagma) are tablets for oral administration has many uses in the treatment of cancer. It is classified as a glucocorticosteroid [2]. Some side effects are common for patients whom administered dexamethasone enhanced the levels of appetite, irritability, difficulty sleeping, swelling in ankles and feet (fluid retention) heartburn, muscle weakness, impaired wound
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
