Effect of maximum blood pressure when discharged from the hospital on the prognosis among patients with acute ischemic stroke

Abstract

To investigate the relationship between maximum blood pressure and the prognosis after discharged from the hospital, among patients with ischemic stroke. A cohort study was conducted which including 471 cases of ischemic stroke patients that were collected from February 2014 to December 2014 at the Second Affiliated Hospital of Harbin Medical University. Values of everyday blood pressure were measured on each patient at the first six days after admitted to the hospital. Maximum blood pressure value of the 6 days was taken as an indicator of the blood pressure levels. The ability on daily living was measured by the modified Rankin score (mRs). Data were analyzed by Chi-square test, t test and multivariate logistic regression analysis. Confounding factors would include age, gender, culture, physical activity, income, smoking, alcohol, hypertension, diabetes, coronary heart disease, stroke history, hospitalization mRs, lipid parameters, homocysteine and blood sugar and were adjusted. Results from multivariate logistic regression analysis showed that the maximum SBP was associated with adverse outcomes. Compared with 140-159 mmHg for SBP, OR (95% CI) was 2.51 (1.30-4.85) for 160-179 mmHg, OR (95% CI) was 2.68 (1.27-5.65) for those pressure levels higher than 180 mmHg, after multiple factors were adjusted. Compared with 90-99 mmHg for DBP, OR (95% CI) was 1.92 (1.00-3.67) for 100-109 mmHg, OR (95% CI) was 2.78 (1.35-5.69) for the ones higher than 110 mmHg. Maximum blood pressure during hospitalization might be associated with adverse outcome of ischemic stroke patients.