Abstract
Materials and methods twelve newborn female Wistar rats were used, and half of them submitted to saline solution administration (control) and the other half were administrated monosodium glutamate solution, 4.0 mg/Kg body weight (obese) in neonatal period. At adult age (90 days of life) these female rats were mated with health male rats and the male offspring were used, divided into two groups: control (CONT, n=29) and obese (OB, n=19), according to its previous dam group. In all adult age (from 3rd to 7th months) the rats were monthly evaluate the Lee Index, water and food intake, 12h-fasting glycemia, oral glucose tolerance test (OGTT) and insulin test tolerance (ITT). In addition, from OGTT Results it was estimated the area under the glycemic curve (AUC). All data were statistically analyzed with 5% significance.
Highlights
Open AccessEffect of maternal obesity on insulin action in male adult offspring rats Eduardo Kloppel*, Yuri Karen Sinzato, Debora Cristina Damasceno, Gustavo Tadeu Volpato, Kleber Eduardo Campos
Obesity is a metabolic disturbance that more affects the population in 21st century
From oral glucose tolerance test (OGTT) Results it was estimated the area under the glycemic curve (AUC)
Summary
Effect of maternal obesity on insulin action in male adult offspring rats Eduardo Kloppel*, Yuri Karen Sinzato, Debora Cristina Damasceno, Gustavo Tadeu Volpato, Kleber Eduardo Campos. From 20th Brazilian Diabetes Society Congress Porto Alegre, Brazil. From 20th Brazilian Diabetes Society Congress Porto Alegre, Brazil. 11-18 November 2015
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