Abstract
4-tert-octylphenol (OP) is environmental pollutants that have been shown widespread impact estrogenic and toxic to the cells of mammals in culture. The effects of OP on the reproductive system of adult male vertebrates especially humans are virtually unknown. Thus, in the present investigation, pregnant females of albino rats were orally treated during pregnancy and until 21 days after birth (the period of lactation) with octylphenol (OP) at doses 0 (vehicle: corn oil), 40 mg/kg and 120 mg/kg on the epididymis of male rats at puberty (12 weeks of age). The present result showed that there is non-significant in the number; the size of newborn rats and there increased in mortality rate of newborn rats of the pregnant female treatment with dose low-and high-octylphenol compared to the control group. there is increased in the average body weight and percentage of gain in body weight of male rats from mothers of small treatment (G2, G3) and the control group (G1) for 12 weeks of age. Also, histological results showed that the adrenal gland in the group which was given high dose of octylphenol (G3) show that Severe histological changes in the cortex. When examining medulla and found large areas of necrosis and cell degradation, necrosis and cell death sharply.
Highlights
An environmental pollutant, 4-tert-octylphenol (OP) [p-(1,1,3,3-tetramethylbutyl)-phenol], an endocrine-disrupting chemical, is an alkylphenolic compound derived as one of the major biodegradation products of nonionic surfactants, alkylphenol polyethoxylates (APEOs)
The present result showed that there is non-significant in the number; the size of newborn rats and there increased in mortality rate of newborn rats of the pregnant female treatment with dose low-and high-octylphenol compared to the control group. there is increased in the average body weight and percentage of gain in body weight of male rats from mothers of small treatment (G2, G3) and the control group (G1) for 12 weeks of age
The present results showed that there is non-significant in the number and the size of newborn rats of the pregnant female treatment with dose low-and high-4-tertoctyl phenol compared to the control group and did not observe any superficial changes or behavioral on newborns male rats during the period of infancy through adulthood
Summary
4-tert-octylphenol (OP) [p-(1,1,3,3-tetramethylbutyl)-phenol], an endocrine-disrupting chemical, is an alkylphenolic compound derived as one of the major biodegradation products of nonionic surfactants, alkylphenol polyethoxylates (APEOs). These APEOs are released to the environment from the use of many chemicals such as detergents, paints, plastics, herbicides, and pesticides, and have become a major component in wastewater systems [1,2]. Where it is known that the natural functions of all organs of the body regulated by hormones secreted by the endocrine system, the disturbances simple functions and especially during the critical stages of the life cycle such as configuration development and pregnancy gestation and lactation will lead to severe damage and longterm effects on those organs in animals land and rights [9,12,13]. Batarfi / Advances in Biological Chemistry 2 (2012) 51-57 in adrenal glands of these newborn rats
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