Abstract
IN appropriate conditions single cells obtained by dissociation of embryonic tissues form organised cell masses resembling tissues. We wish to present results indicating that the adhesive properties of chick embryonic cells depend on maternal age. These unexpected observations were made in studies on the mechanism of intercellular adhesion. The formation of initial aggregates between chick embryonic liver cells is a two-step process1; cells rapidly and reversibly bind to each other to form aggregates in a step that is not inhibited by metabolic poisons. The reversibly bound cells are then converted into stably bound cells in a process requiring metabolic energy.
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