Effect of mast cells on interleukin-1 production by exudate and bone marrow macrophages in inflammation

Abstract

It was shown on the model of acute infectious peritonitis in mice that the inflammation induced in the absence of mast cells was characterized by an earlier interleukin-1 (IL-1) production by bone marrow macrophages and by the lack of relapsed IL-1 production by macrophages of both exudate and bone marrow. This correlated with the previous data of the authors on the earlier haematopoiesis activation but weaker bone marrow hyperplasia expression in inflammation induced in the absence of mast cell. The results testify to essential role of mast cells in regulation of IL-1 production by macrophages of exudate and bone marrow. The previously established modulatory effect of mast cells on haematopoiesis in inflammation may be mediated by their effect on IL-1 production by macrophages of the inflammatory focus and haematopoiesis-induced microenvironment.