Abstract
Clinical trials were designed to examine the question of whether progestational hormone treatment distinctly and predictably affects the already evolved spontaneous activity of the parturient human uterus. The specific question was whether a single massive dose of a potent progestational hormone predictably suppresses the activity of the parturient human uterus. 62 patients were in the completed study 38 controls and 24 hormone-treated patients. Only those patients were placed in the study group who displayed advanced spontaneous activity during early labor. After spontaneous activity had been recorded for 1 hour the patients received intramuscularly a single massive dose of a potent progestational hormone medroxyprogesterone acetate (MPA). The intraamniotic pressure was continuously measured after the administration of the hormone until the time of delivery. The difference at 5 and 10 hours after hormone treatment was statistically significant. The control curve had a slight upward tendency; the experimental curve a slight downward tendency. In that these curves represent averages the position of any single point along the curve is determined by the position of the majorty of points at this particular time. Thus the eventual acceleration of activity at the end of labor of the MPA-treated individual patients was masked by the low average activity of those women in whom acceleration had not yet occurred. Considering averages it appears that massive MPA treatment induced a slight and transient damping effect on uterine activity during early labor.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.