Abstract
Abstract The effects of Malus halliana Koehne polysaccharides on functional constipation was investigated in this study. The rats were divided into six groups: normal group, model group, positive control group, M. halliana polysaccharides high dose groups 1200 mg/ kg, medium dose groups 1000 mg/ kg and low dose groups 800 mg/kg. The model of constipation was established by loperamide hydrochloride. Feces weight at 6 and 24 hours after treatment, Colon moisture content, in addition the levels of motilin (MTL), gastrin (Gas), somatostatin (SS), substance P (SP) in serum were used to evaluate the preventive effects of M. halliana polysaccharides on constipation. Compared with the model group, the positive control group, M. halliana polysaccharide high, medium and low dose group 6 h weight of feces, colon moisture content, the levels of motilin (MTL), gastrin (GAS) and substance P(SP) significantly (p <0.01) increased, the levels of somatostatin (SS) significantly decreased. The results indicated that the high, middle and low dosage of M. halliana polysaccharide could effectively improve functional constipation. Amongst these doses, the low dose group was better than others.
Highlights
Constipation is a common gastrointestinal disorder, which is a more complex pathogenesis, based on mainly gastrointestinal disturbance
The results showed that the positive control group, M. halliana polysaccharides high, medium and low dose group had a therapeutic effect on constipation
Clinical manifestations of functional constipation mainly defecation effort, fecal dry knot, a sense of defecation and anorectal obstruction or obstruction can be manifested as reduced the amount of defecation and frequency, which affects the appetite and intestinal absorption of patients, and can induce or aggravate colon cancer, cardiovascular and other diseases
Summary
Constipation is a common gastrointestinal disorder, which is a more complex pathogenesis, based on mainly gastrointestinal disturbance. Previous studies show that polysaccharides have some therapeutic effect on constipation such as Long C.X. et al [9] found that Dendrobium candidum polysaccharide. This work is licensed under the Creative Commons Attributioncould enhance the body immunity, regulate the balance of intestinal microbiota and intestinal enzyme activity, optimize the intestinal environment and improve the symptoms of spleen constipation. Luo D.D. et al [10] studies show that the polysaccharide of D. officinalis has the laxative activity to constipated mice. Pharmacological studies showed that M. halliana had the ability of protect liver, antioxidant, inhibition of α-glycosidase enzymes in vitro and antithrombotic effect in vivo [16,17,18]. The M. halliana flower’s polysaccharides were extracted and investigated on functional constipation
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