Abstract
Rats maintained on a diet from which pyridoxine was omitted were more susceptible to Trypanosoma cruzi infection than were normal or pair-fed control rats. A higher, more persistent parasitemia and greater degree of myocarditis were observed most frequently in pyridoxine-deficient rats. Although increased age resulted in a reduced susceptibility of control animals to infection, rats inoculated after 6 weeks on a pyridoxine-deficient diet were equally as susceptible to infection as those which were infected after 3 weeks on diet. Spontaneous respiratory infection occurred more frequently in the pyridoxine-deficient animals. The incidence of this infection was the same whether or not the rats were inoculated with T. cruzi.
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