Abstract
An electron microscope study of the effect of sublethal concentrations of malathion on the length of active zones has been performed in synapses of forebrain in the goldfish and rainbow trout. There was established a statistically significant reversible decrease of the main values of the length of sections of active zones in asymmetric and symmetric synapses under action of the toxicant. Effect of malathion increases proportionally to an increase of its concentration. In the both fish species the response to malathion was more pronounced in the asymmetric synapses compared to the symmetric ones. The obtained results allow considering that malathion causes changes in configuration and dimensions of the active zones of the cholinergic and probably GABAergic synapses. An adaptive character of these changes is discussed.
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