Abstract

The effect of malathion on oxygen consumption by liver and kidney slices, and on cholinesterase enzyme (ChE) of plasma and red blood cells (RBC) has been investigated in hens. Single oral doses of 262.40 and 393.60 mg/kg (equivalent to 50% and 75% of the LD50 respectively), resulted in an initial rise of plasma cholinesterase followed by a fall. The RBC cholinesterase on the other hand was significantly inhibited right from the beginning. The plasma enzyme activity recovered earlier returning to almost normal values in six to eight days while the RBC enzyme continued to be significantly inhibited even after ten days. Six hours after a single oral dose of malathion, the oxygen consumption by liver slices was significantly inhibited and inhibition persisted up to 36 hours. Thereafter, it gradually returned to normal values in the next 36 hours. No change in oxygen consumption by kidney slices was observed.

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