Effect of Mahkota Dewa Ethanolic Extract (Phaleria macrocarpa) to Kidney Histology of Preeclampsia Rats

Abstract

Hypertension is an increase in systolic and diastolic pressure, the height of which depends on the age of the individual affected. Hypertension can also cause terminal kidney failure (GGT). One of the herbs that has the effect of reducing blood pressure is the mahkota dewa. This study aims to determine the effect of mahkota dewa extract on histological and morphological features of the kidneys in preeclampsia rat. In this study using a type of analytic research with quasi-experimental design in pregnant rat (Rattus novergicus) as many as 24 rats and consisted of 4 treatments (each treatment was divided into 6 rats). control group, P1 (pregnant rats injected by LPS) P2 (pregnant rats injected with LPS given 100 mg / BW of mahkota dewa extract once a day) and P3 (pregnant rats injected with LPS and given 200 mg/BW of deity extract twice a day). On the 17th day the pregnancies of the rat were dissected and taken by kidney organs and then made a paraffin method preparation using Hematoxylin-Eosin (HE) staining. Morphological observations showed a change in color in group K (control) = blackish red, at P1 = pale red, P2 = brownish red and P2 = thick red While the results of kidney histology on tubular narrowing and necrosis obtained significant results (P <0,05) between P1 and P3. This shows that the mahkota dewa is very influential on kidney damage in preeclampsia models.