Effect of Magnetic Field on Blood Oxygen Transport Function during a Hydrogen Sulfide Donor Introduction

Abstract

Gas transmitters (hydrogen sulfide, H2S, nitric oxide, NO) belong to gaseous signaling compounds, which are important for transduction of physiological signals. However, contribution of hydrogen sulfide to effects of magnetic field (MF) on oxygen transport function is still poorly understood. So, the effect of magnetic field on oxygen transport function of the blood upon the administration of a hydrogen sulfide donor was evaluated in the work. The tail artery of outbred white male rats was exposed to MF, and the drugs affecting hydrogen sulfide formation, namely, sodium hydrosulfide (NaHS); L-arginine; NG -nitro-L-arginine methyl ester (L-NAME), a nonselective inhibitor of NO synthase; and DL-propargylglycine (PAG), an irreversible inhibitor of cystathionine-γ-lyase were injected intraperitoneally for 10 days. Oxygen transport function of the blood, the contents of hydrogen sulfide and nitrate/nitrite anions (NO2− /NO3−) were determined in the blood plasma. It has been shown that an exposure of rats to MF and administration of either NaHS or amino acid L-arginine leads to a decrease in the affinity of hemoglobin for oxygen and is accompanied by an increase in the content of gas transmitters (NO and H2S) in the blood. With the introduction of L-NAME and PAG, the effect of MF on the affinity of hemoglobin for oxygen is not manifested. Thus, MF realizes its effect through the hydrogen sulfide and nitric oxide.