Effect of magnetic dipolar interactions on temperature dependent magnetic hyperthermia in ferrofluids

Abstract

Magnetic hyperthermia (MHT), where localized heating is generated when magnetic nanoparticles (MNPs) are subjected to a radiofrequency magnetic field, has a great potential as a non-invasive cancer therapy treatment. The efficiency of heat generation depends on the magnetic properties of MNPs, such as saturation magnetization (Ms) and magnetic anisotropy (K), as well as the particle size distribution and magnetic dipolar interactions. We have investigated MHT in two Fe3O4 ferrofluids prepared by co-precipitation (CP) and hydrothermal (HT) synthesis methods showing similar physical particle size distribution (14 ± 4 nm) and saturation magnetization (70 ± 2 emu/g of Fe3O4) but very different specific absorption rates (SAR) of ∼110 W/g and ∼40 W/g at room temperature (measured with an ac magnetic field amplitude of 240 Oe and a frequency of 375 kHz). This observed reduction in SAR has been explained by taking into account the dipolar interactions and the distribution of the magnetic core size of MNPs in ferrofluids. The HT ferrofluid shows a higher effective dipolar interaction and a wider distribution of the magnetic core size of MNPs compared to those of the CP ferrofluid. We have fitted the temperature dependent SAR data using the linear response theory, incorporating an effective dipolar interaction, to determine the magnetic anisotropy constant of MNPs prepared by CP (22 ± 2 kJ/m3) and HT (26 ± 2 kJ/m3) synthesis methods. These values are in good agreement with the magnetic anisotropy constant determined using frequency and temperature dependent magnetic susceptibility data obtained on powder samples.