Abstract
The present study is designed to investigate whether magnesium (Mg) supplementation may prevent Cd-induced alterations in zinc (Zn), copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of Zn, Cu, and Mg were estimated in blood, urine, and organs (brain, heart, lungs, liver, kidney, spleen, pancreas, skeletal muscle, and bone) of rabbits given Cd (10 mg/kg b.w.) and rabbits cotreated with Mg (40 mg/kg b.w.) orally, as aqueous solutions of Cd chloride and Mg acetate every day for 4 weeks. Samples were mineralized with conc. HNO3 and HClO4 (4:1) and metals concentrations were determined by atomic absorption spectrophotometry (AAS). Magnesium supplementation succeeded to overcome Cd-induced disbalance of investigated bioelements. Beneficial effects of Mg were observed on Zn levels in blood and urine, on Cu levels in urine, and on Mg levels in blood. Magnesium pretreatment also managed to counteract or reduce all Cd-induced changes in levels of Cu and Mg in organs, while it did not exert this effect on Zn levels. These findings suggest that enhanced dietary Mg intake during Cd exposure can have at least partly beneficial effect on Cd-induced alterations in homeostasis of zinc, copper, and magnesium.
Highlights
Over the past several decades, numerous experimental and epidemiological studies on cadmium (Cd), as an important environmental and occupational toxicant, demonstrated multiple mechanisms of Cd toxicity
These findings suggest that enhanced dietary Mg intake during Cd exposure can have at least partly beneficial effect on Cd-induced alterations in homeostasis of zinc, copper, and magnesium
The literature data indicate that enhanced Zn intake reduced Cd body burden [14, 15], had beneficial effect on lipid peroxidation induced by Cd [13] or skeletal properties impaired by Cd [16], and had even protective effect against Cd-induced carcinogenicity [4]
Summary
Over the past several decades, numerous experimental and epidemiological studies on cadmium (Cd), as an important environmental and occupational toxicant, demonstrated multiple mechanisms of Cd toxicity. The literature data indicate that enhanced Zn intake reduced Cd body burden [14, 15], had beneficial effect on lipid peroxidation induced by Cd [13] or skeletal properties impaired by Cd [16], and had even protective effect against Cd-induced carcinogenicity [4]. Investigated in less extent, there are evidences on beneficial effect of magnesium (Mg) supplemental intake on Cd toxicity. Magnesium reduced Cd concentration and lipid peroxidation and had even protective effect against carcinogenicity and teratogenicity of Cd in experimental animals as reviewed by Matovicet al.
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