Abstract
BackgroundThe benefits of intraoperative magnesium supplementation have been reported. In this prospective, randomized study, the effects of magnesium supplementation during general anaesthesia on emergence delirium and postoperative pain in children were evaluated.MethodsA total of 66 children aged 2 to 5 years who underwent strabismus surgery were assigned to the magnesium or to the control group. Preoperative anxiety was assessed using the modified Yale Preoperative Anxiety Scale. After anaesthesia induction, the magnesium group received an initial loading dose of 30 mg/kg magnesium sulphate over 10 min and, then, continuous infusion of 10 mg/kg per h until 10 min before the end of the surgery. The control group received an equal volume of normal saline via the same regimen. The Paediatric Anaesthesia Emergence Delirium (PAED) score, pain score, and respiratory events were assessed at the postanaesthetic care unit.ResultsData obtained from 65 children were analyzed. The PAED and pain scores of the two groups did not differ significantly. There were 26 of 33 (78.8%) and 27 of 32 (84.4%) children with emergence delirium in the control and the magnesium groups, respectively (odds ratio 0.69, 95% CI 0.19–2.44; p = 0.561). The preoperative anxiety score was not significantly correlated with the PAED score. The incidence of respiratory events during the emergence period did not differ significantly between the two groups.ConclusionsMagnesium supplementation during anaesthesia had no significant effects on the incidence of emergence delirium or postoperative pain in children undergoing strabismus surgery.Trial registrationClinicalTrials.gov (NCT03132701). Prospectively registered May 8, 2017.
Highlights
The benefits of intraoperative magnesium supplementation have been reported
It has been associated with fast-acting inhalation anaesthetics, such as sevoflurane or desflurane, male sex, ophthalmology and otolaryngology procedures, younger age, and preoperative anxiety, and its incidence has been shown to be reduced by intraoperative opioids, benzodiazepine, and alpha 2 adrenergic agonists [2]
Apan et al [8] reported that magnesium supplementation had no influence on the incidence of emergence delirium in paediatric patients
Summary
The benefits of intraoperative magnesium supplementation have been reported. In this prospective, randomized study, the effects of magnesium supplementation during general anaesthesia on emergence delirium and postoperative pain in children were evaluated. Emergence delirium after general anaesthesia is a common phenomenon, and rates > 80% have been reported in children [1]. It has been associated with fast-acting inhalation anaesthetics, such as sevoflurane or desflurane, male sex, ophthalmology and otolaryngology procedures, younger age, and preoperative anxiety, and its incidence has been shown to be reduced by intraoperative opioids, benzodiazepine, and alpha 2 adrenergic agonists [2]. Apan et al [8] reported that magnesium supplementation had no influence on the incidence of emergence delirium in paediatric patients
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