EFFECT OF MAGNESIUM SULFATE ON DOPPLER INDICES AND FETAL CIRCULATION IN CASES OF SEVERE PRE-ECLAMPSIA

Abstract

Background: In women with severe PE, the use of magnesium sulfate (MgSO4) is indicated for prevention and control of acute convulsions. Several randomized trials have compared the efficacy of MgSO4 with other anticonvulsants in women with eclampsia, and the rates of recurrent seizures and maternal death significantly reduced with MgSO4 as compared with other anticonvulsants. Objective: To assess the effect of magnesium sulfate injection on Doppler indices and fetal circulation in cases of severe pre-eclampsia. Patients And Methods: This was a prospective study that conducted on one hundred pregnant women suffering from pre-eclampsia, selected from the Obstetrics and Gynecology Department of Al-Hussein University Hospital from January 2018 to December 2018, evaluated before and after administration of magnesium sulfate, Doppler ultrasound was carried out to measure umbilical artery blood flow. Results: The results showed that a significant improvement in Doppler measurements and out come with treated groups (MgSO4) group more than the control group. Conclusion: MgSO4 proved to cause many hemodynamic changes as it has a vasodilator effect on maternal and fetal blood vessels. Doppler indices in the umbilical arteries significantly changed after administration of MgSO4 in patients with severe preeclampsia.