Abstract
Incorporation of trace elements into calcium phosphate structure is of great interest for the development of artificial bone implants. Biphasic calcium phosphate (BCP) composed of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) have been synthesized in the presence of magnesium (5 M% - 20 M%) by gel method under physiological conditions. Crystallization of Mg-BCP in the gel medium mimics the Mg intake in the human body. Powder X-ray dif- fraction and Fourier transform infrared analyses confirmed that the Mg doping leads to the enrichment of β-TCP phase and suppresses the HA content in BCP. Nanoindentation studies indicate a significant decrease in hardness and elastic modulus values of BCP due to Mg doping. In vitro bioactivity study has confirmed the formation of apatite layer on the Mg doped samples making it suitable for bone replacement. The results suggest that the optimum Mg doping promotes the bioactivity which is perquisite for biomedical applications.
Highlights
Biphasic calcium phosphate (BCP) composed of a mixture of hydroxyapatite (HA, Ca10(PO4)6(OH)2) and β-tricalcium phosphate (β-TCP, β-Ca3(PO4)2) are interesting candidates in reconstructive surgery [1,2,3]
Earlier we have demonstrated that the strontium (Sr) doped BCP synthesized by gel method was free from these impurities [10]
Biphasic calcium phosphate consisting of HA and β-TCP was successfully synthesized by gel method
Summary
Biphasic calcium phosphate (BCP) composed of a mixture of hydroxyapatite (HA, Ca10(PO4)6(OH)2) and β-tricalcium phosphate (β-TCP, β-Ca3(PO4)2) are interesting candidates in reconstructive surgery [1,2,3]. They are suitable for synthetic bone substitution applications because the HA provides a permanent scaffold for new bone formation via osteoconduction and the resorption of the β-TCP oversaturates the local environment with Ca2+ and PO34 ions to accelerate this new bone formation. Several methods have been reported to prepare Mg substituted HA, β-TCP and BCP [6,7,8,9]. Effect of Mg addition on the HA/β-TCP ratio, morphology, bioactive properties and mechanical behavior of BCP have been investigated
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