Abstract
To evaluate the association between macular hole volume (MHV) and postoperative central macular thickness (CMT) using spectral-domain optical coherence tomography (SD-OCT). Thirty-three eyes of 30 patients with a large full-thickness idiopathic macular hole with or without vitreomacular traction who underwent surgical intervention were included in this cross-sectional study. Complete ophthalmological examination, including SD-OCT, was performed for all participants during the pre- and postoperative visits. MHV was preoperatively measured using SD-OCT, which captured the widest cross-sectional image of the hole. For normal distribution analysis of the data, the Kolmogorov-Smirnov test was performed, and for statistical analyses, chi-square, Student's t-test, Mann-Whitney U test, and Pearson's correlation coefficient test were performed. Mean preoperative best-corrected visual acuity (BCVA) and MHV were found to be 0.99 ± 0.36 (range, 0.3-2.0) logMAR and 0.139 ± 0.076 (range, 0.004-0.318) mm3, respectively. Mean follow-up was 16.3 ± 14.3 (range, 3-50) months. No statistical correlations were found between MHV and postoperative BCVA (p=0.588) and between MHV and disease recurrence (p=0.544). A weak negative correlation existed between MHV and final CMT scores (p=0.04, r=-0.383). Greater MHV was found to be weakly associated with lower postoperative CMT scores.
Highlights
Major causes for developing a macular hole (MH) include anteroposterior forces applied by vitreofoveal traction and tangential traction from involutional changes in the inner retina[1,2,3,4]
This study aimed to evaluate the association between macular hole volume (MHV) and postoperative central macular thickness (CMT) using Spectral-domain optical coherence tomography (SD-OCT)
Thirty-three eyes of 30 patients with a diagnosis of large full-thickness idiopathic MH with or without vitreomacular traction (VMT) who underwent chromovitrectomy combined with internal limiting membrane (ILM) peeling and intraocular sulfur hexafluoride (SF6) tamponade in our Retina Unit between January 2010 and December 2012 were included in this study
Summary
Major causes for developing a macular hole (MH) include anteroposterior forces applied by vitreofoveal traction and tangential traction from involutional changes in the inner retina[1,2,3,4]. Macular atrophy may be responsible for inferior visual outcomes; the foveal microstructure has to be well identified in patients with MH prior to any surgical intervention. Using SD-OCT imaging in the diagnosis of MH augments clinical staging by enabling visualization of the foveal and vitreous microstructure and the tractional association between them and calculating macular hole dimensions. The impact of preoperative OCT measurements on diagnosing or staging idiopathic MH and its predictive value for postoperative anatomical and functional outcomes have been previously investigated[14,15,16,17,18,19,20,21,22,23,24]. To the best of our knowledge, no study has elucidated the association between preoperative macular hole volume (MHV) and postoperative macular atrophy as a tool for predicting postoperative visual outcome. This study aimed to evaluate the association between MHV and postoperative central macular thickness (CMT) using SD-OCT
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