Abstract
The influence of lysine vasopressin (LVP) andACTH<sub>4–10</sub> treatment on avoidance acquisition in a shuttle-box was studied in hypophysectomized rats. Both peptides restored the impaired avoidance acquisition of such animals. Cessation of treatment resulted in a progressive decrease of avoidance performance of ACTH<sub>4–10</sub> treated rats, despite shock reinforcement if no avoidance occurred. In contrast, cessation of LVP administration did not affect subsequent avoidance behavior. Accordingly, ACTH analogues have a short-term and LVP a long-term effect on avoidance acquisition. It is suggested that ACTH analogues restore fear motivation, while LVP is involved in the consolidation of aversively motivated learning processes.
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