Abstract
Mitochondrial porin is a complex channel with many diverse functional properties. Therefore, along with measuring single-channel conductance and selectivity, monitoring VDAC's voltage gating has become the gold standard for assessing mitochondrial porin function. To understand the mechanisms of gating and ion selectivity, the detergent-solubilized porin was incubated with different concentrations of diethylpyrocarbonate (DEPC). The extent of the reaction of DEPC with histidine residues
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