Abstract
THE resolution of factors influencing the release of the adrenocorticotrophic hormone (ACTH) is a problem of continuing interest among investigators. It is noteworthy that destructive lesions in the hypothalamus (De Groot and Harris, 1950; Hume and Wittenstein, 1950; Porter, 1953; McCann, 1953; McCann and Sydnor, 1954; Ganong and Hume, 1954; and Laqueur et al., 1955), pituitary transplants (Harris and Jacobsohn, 1952 and Jacobsohn, 1954), and tissue cultures of the anterior lobe (Guillemin, 1955) suggest that the hypothalamus is of significance in regulating ACTH secretion, possibly by means of a neurohumoral substance (Hinsey and Markee, 1933 and Green and Harris, 1947). The vascular requirements for the direct transport of such a blood-borne substance from the hypothalamus to the anterior lobe are present as portal vessels (Wislocki and King, 1936; Green and Harris, 1947, 1949; and Xuereb et al., 1954). It has been observed that plasma from the hypothalamicohypophyseal portal vessels promotes the releas...
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