Abstract
Objective: To assess the histological alterations in basement membrane and fibrosis in renal interstitium of albino rats due to celebrex with enhancement by lycopene. 
 Study Design: Experimental study.
 Abode of Study: Animal House of Jinnah Postgraduate institute, Karachi,
 Materials and Methods: COX-2 inhibitor and antioxidant medicines were used in this research work. These medications were orally administered in 40 male albino rats weighing 200-220gm for experimentation. Rats were housed in separate pens at 23ºC. Rats were arranged into 4 groups including control horde and three experimental hordes. The medications were dose up orally by gastric tube daily for one month. At completion of experiment, animals were dissected and tissues were well-preserved for staining.
 Results: In second horde PAS stained kidney segments showed disrupted basement membrane of distended proximal convoluted tubules & ill-defined brush border and fibrosis in renal interstitium, but 3rd horde had intact basement membrane & well-define brush border at the luminal surface of proximal tubular epithelium and there was mild fibrosis in renal interstitium.
 Conclusion: This study divulges that lycopene convalesce the disrupted basement membrane and fibrosis in second horde.
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