Effect of LY53857, a selective 5HT 2 receptor antagonist, on 5HT-induced increases in cutaneous vascular permeability in rats

Abstract

Both serotonin and histamine increased cutaneous vascular permeability in rats; however, serotonin was approximately 100-fold more potent than histamine. LY53857 (0.1 and 1.0 mg/kg, i.p.), a selective 5HT 2 receptor antagonist, blocked serotonin- but not histamine-induced increases in cutaneous vascular permeability. The alpha 1 receptor antagonist, prazosin, did not significantly affect increases in vascular permeability produced by serotonin. These data extend previous studies with LY53857 by further documenting its selectivity as a 5HT 2 receptor antagonist. In addition, these results with a selective 5HT 2 receptor antagonist provide evidence that 5HT 2 receptor activation may be the predominent mechanism associated with vascular permeability changes induced by serotonin.