Abstract
THE anatomical changes which occur in the lung during deep inspiration and expiration are the subject of some argument. Macklin1 considered that during inspiration the main increase in volume occurred in the alveolar ducts, and that the alveoli underwent little or no stretching but merely became “shallower and wider at the mouth when the tube into which they open dilated”. This view has been challenged by Storey and Staub2, who showed, using rapid freezing techniques in the lungs of living cats, that the mean alveolar diameter increased during inspiration. They concluded that the surface area of the alveoli increased correspondingly. The alveolar surface area has not hitherto been measured directly in varying degrees of inflation.
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