Abstract
Recent studies have shown that the rate of colonic cell renewal can be altered through fasting and refeeding, which produces a marked depression and transient stimulation, respectively. In the present study, the role of physical versus nutritional stimulation in the colonic fasting-refeeding response and the renewal of the functional colonic compartment were evaluated via a nondestructive colonic ligation procedure. The results reported herein suggest that physical stimulation by lumenal factors is in part required to initiate the colonic hyperplasia seen after refeeding. Blood-borne nutritional factors, in the absence of physical stimulation, cannot alone stimulate colonic cell production. Additional evidence is presented which suggests that this physical stimulation may be manifested through the lumenal distension produced by the newly ingested food materials. The results are discussed from the viewpoint of influencing the functional colonic compartment and physiological capacity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
