Abstract
The study evaluated the effects of Mimusa pudica (M. pudica) leaf extract on type 2 diabetes in rats fed high fructose diet (HFD). Rats were fed either control diet or HFD for 14 days, following which the diet was fortified with M. Pudica at a dose of 500 mg/kg BW. After 8 weeks, HFD caused deleterious metabolic effects, including increased body weight, hyperglycemia, hyperinsulinemia, dyslipidemia and liver dysfunction. Further, rats fed HFD alone showed increased activities of hepatocellular enzymes in plasma and lipid deposition in liver. Treatment with M. pudica significantly reduced the body weight, improved insulin sensitivity, managed the dyslipidemia and reduced liver damage towards normal. Histopathology of the liver confirmed the changes induced by HFD and the M. pudiac treatment significantly reversed towards normality. These data suggest that M. pudica treatment improve insulin sensitivity and attenuates fat accumulation in liver.
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