Effect of low-intensity resistance training with blood flow restriction on serum VEGF level, bone markers and bone mineral density in elderly women

Abstract

Purpose The purpose of this study was to investigate the effects of low-intensity resistance training with blood flow restriction on serum VEGF, bone markers and bone mineral density in elderly women. Methods The subjects were divided into three groups: low-intensity resistance training with blood flow restriction(BFR-LRT, n=8); high intensity resistance training(HRT, n=8); low- intensity resistance training (LRT, n=5). Both the BFR-LRT and LRT groups worked out knee extension and leg curl exercises at 20% of each estimated one-repetition maximum(1RM) and HRT group worked out knee extension and leg curl exercises at 70% of each estimated 1RM 3 days per week for 12 weeks. Results As a result after 12 weeks, serum VEGF level have increased significantly among BFR-LRT group compared to HRT and LRT groups. Serum Bone ALP level have increased significantly among BFR-LRT and HRT groups compared to LRT group. Calcaneus BMD have increased significantly among BFR-LRT and HRT groups compared to LRT group. Conclusions In conclusion, despite using low-intensity load, BFR-LRT is a efficient training alternative to HRT for improving bone metabolism in older women.