Effect of Low-Intensity Laser Irradiation on the Process of Bone Repair

Abstract

The effect of low-intensity laser (GaAsAl) irradiation on bone repair in the femurs of mice was investigated. An experimental model of hole injury with surgery drills was used in 20 mouse femurs followed by a study of the effect of low-energy laser irradiation on bone repair. The experimental model was divided into two groups. The first (10 left femurs) received laser irradiation immediately after injury and was followed for different time intervals (24, 48, and 72 h). The right femurs (control group) underwent hole injury but no laser irradiation. The rats were sacrificed after 14 days and the results were analyzed using a quantitative histometrical method. The Mann-Whitney test was used to perform the statistical analysis. Histometrical analysis revealed a more rapid accumulation of reparative new bone in the hole injury of the laser-irradiated legs. We conclude that GaAsAl laser irradiation after injury was effective on bone repair when compared to results in the control group.