Abstract
Studying of the effects of low doses of γ-irradiation is a crucial issue in different areas of interest, from environmental safety and industrial monitoring to aerospace and medicine. The goal of this work is to identify changes of lifespan and expression stress-sensitive genes in Drosophila melanogaster, exposed to low doses of γ-irradiation (5 – 40 cGy) on the imaginal stage of development. Although some changes in life extensity in males were identified (the effect of hormesis after the exposure to 5, 10 and 40 cGy) as well as in females (the effect of hormesis after the exposure to 5 and 40 cGy), they were not caused by the organism “physiological” changes. This means that the observed changes in life expectancy are not related to the changes of organism physiological functions after the exposure to low doses of ionizing radiation. The identified changes in gene expression are not dose-dependent, there is not any proportionality between dose and its impact on expression. These results reflect nonlinear effects of low dose radiation and sex-specific radio-resistance of the postmitotic cell state of Drosophila melanogaster imago.
Highlights
Throughout the history of living things, the natural background radiation of the Earth and cosmic rays have been one of the key environmental factors that have affected the rate of evolutionary processes [1, 2]
Lifespan alterations in Drosophila melanogaster wild-type Canton-S individuals after the exposure to low doses of γ-irradiation In Drosophila melanogaster wild-type Canton-S males, after exposure to low doses of ionizing radiation, we have observed the effect of hormesis: after the influence of γ-irradiation at a dose of 10 cGy, median lifespan increased by 3.4% (p
There were changes in various indicators of life expectancy after exposure to 5, 10, 20 and 40 cGy, according to our analyses, they were not caused by the changes of organism physiological functions in the Drosophila melanogaster individuals after treatment, and there were not dose-dependent changes in the expression profile of stress-response genes chosen for the present study
Summary
Throughout the history of living things, the natural background radiation of the Earth and cosmic rays have been one of the key environmental factors that have affected the rate of evolutionary processes [1, 2]. Additional sources of irradiation are present in medical procedures, air PLOS ONE | DOI:10.1371/journal.pone.0133840 August 6, 2015
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