Effect of low dose intravenous ketorolac tromethamine combined with phloroglucinol in the treatment of renal colic

Abstract

Objective To study the effect of low dose intravenous ketorolac tromethamine combined with phloroglucinol on relieving renal colic treatment.Methods 140 patients with renal colic were randomly divided into 3 groups receiving intravenous 30 mg ketorolac tromethamine/80 mg phloroglucinol (Group Ⅰ,n=46),60 mg ketorolac tromethamine/80 mg phloroglucinol (Group Ⅱ,n=47) or intramuscular 100 mg pethidine/intravenous 10 mg anisodamine (Group Ⅲ,n=47) respectively.Analgesic effect,pain relief time,side-effect of therapy were observed in all patients after administration of 10,20,40 mins respectively.Results The rate of pain relief and total efficiency in group Ⅰ were significantly higher than that of group Ⅱ and group Ⅲ at 10 min after administration(19.56％ vs 0,8.51％,P=0.005) (76.9％ vs 40.42％,55.31％,P--0.002).No significant difference was found among 3 groups at 40 min after administration (P=0.861,P=-0.869).The pain relief time in group Ⅰ was significantly shorter than those of group Ⅱ and group Ⅲ [(14.3 ± 9.5) mins vs (23.8 ± 5.4) mins,(18.2 ± 8.3) mins] (F =46.32,P＜0.05).Incidences of sideeffect of group Ⅰ and group Ⅱ were significantly lower than that of group Ⅲ (8.69％,14.89％ vs 82.97％,P=0.000).Conclusion Low dose intravenous ketorolac tromethamine combined with phloroglucinol is effective in the early treatment of renal colic with less side-effect. Key words: Ketorolac tromethamine; Phloroglucinol; Renal colic; Intravenous