Abstract
Objective To observe the effect of low-dose arsenious acid combined with retinoic acid on the expression and methylation level of p15INK4B gene in childhood myelodysplastic syndromes (MDS). Methods 11 children with MDS induced by low-dose arsenious acid and retinoic acid were enrolled. The expression and methylation level of p15INK4B gene were detected by real time fluorescence quantitative PCR (RT-PCR). Results There were 9 patients in 11 cases benefited from the bi-induction regimen. The p15INK4B expression was increased in 10 MDS patients after treatment, but there was no significant difference [(1.68±0.58)% vs (1.44±0.65)%, t=-0.885, P>0.05)]. Conclusions The low-dose arsenious acid combined with retinoic acid has favorable effect for the treatment of childhood MDS. Its mechanism may be related with the increased expression level of p15INK4B, however, methylation level is not associated with the increased expression of p15INK4B. Key words: Myelodysplastic syndromes; p15INK4B gene; Methylation; Child; Arsenious acid combined with retinoic acid
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