EFFECT OF LOW AND HIGH CONCENTRATIONS OF ALFENTANIL ADMINISTERED INTRATHECALLY ON Aδ AND C FIBRE MEDIATED SOMATOSYMPATHETIC REFLEXES

Abstract

We have studied the effects of alfentanil administered intrathecally on somatosympathetic reflexes evoked by stimulation of radial and tibial nerves in 10 anaesthetized and paralysed dogs. In five animals, alfentanil was administered in doses of 100, 100, 200 and 400 micrograms in 0.8 ml and 800 micrograms in 1.6 ml prepared from the formulation of 500 micrograms ml-1. Five others received alfentanil (high concentration formulation, 5 mg ml-1) in doses of 500 and 2000 micrograms in 0.5 ml and 5000 micrograms in 1 ml. C fibre tibial nerve reflexes were depressed by 100 micrograms and abolished with doses of 200-400 micrograms, but the A delta response remained unaffected. A delta responses were depressed also and abolished, respectively, by doses of alfentanil 2000 micrograms and 5000 micrograms. At the larger, but not the smaller, concentration there was evidence of baroreflex sensitization probably caused by systemic absorption of the drug.