Abstract
An anticholinergic, propantheline bromide, was given in a dosage of 5 mg./ kg. body weight twice daily to rats. Gastric function was studied after 3, 6, 9, and 12 months of this treatment. Gastric content was collected after (1) pyloric and cardia ligation; (2) pyloric ligation only; and (3) during a 24-hr, intravenous infusion of histamine. Under the experimental conditions described, a significant reduction of gastric secretion was found in rats after long-term administration of propantheline bromide. This is considered due to the impairment of gastric secretory function induced by repeated inhibition of gastric secretion over a prolonged period.
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