Abstract
The effect of OROS methylphenidate (OROS MPH, Concerta) [34-43 mg daily; 1.1-1.2 mg/kg/day] on the height and weight of 178 children, ages 6 to 13 years, treated for at least 21 months for attention-deficit/hyperactivity disorder (ADHD) was evaluated at the Massachusetts General Hospital, Boston.
Highlights
The effect of OROS methylphenidate (OROS MPH, Concerta) [34-43 mg daily; 1.11.2 mg/kg/day] on the height and weight of 178 children, ages 6 to 13 years, treated for at least 21 months for attention-deficit/hyperactivity disorder (ADHD) was evaluated at the Massachusetts General Hospital, Boston
Weight showed no increase and body mass index (BMI) decreased slightly in the first 4 months of treatment; weight and BMI remained constant after 4 months, and were on average 1.23 kg less than expected at 21 months
The authors conclude that the effects of prolonged OROS MPH on growth of ADHD children are clinically insignificant, and significant decreases in weight are limited to the first months of therapy, their data show some small adverse effects in the group as a whole
Summary
The effect of OROS methylphenidate (OROS MPH, Concerta) [34-43 mg daily; 1.11.2 mg/kg/day] on the height and weight of 178 children, ages 6 to 13 years, treated for at least 21 months for attention-deficit/hyperactivity disorder (ADHD) was evaluated at the Massachusetts General Hospital, Boston. Subjects (86% having received stimulant therapy previously) were at the expected height for their age at baseline and somewhat heavier than expected.
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