Abstract
The aim was to study the effectiveness of the use of turmeric extract in the composition of the original rectal suppositories in experimental Crohn’s disease (CD) based on the assessment of the clinical picture and indicators of the immune status.Materials and methods. The work was performed on 70 rats of the Wistar line. CD was unduced by the rectal administration of a trinitrobenzenesulfonic acid solution, rectal suppositories with 0.000075 mg of curcumin based on an alcohol solution of rhizome extract with turmeric roots were used after 12 hours for 7 days, in the comparison group rectal suppositories with 50 mg of 5-aminosalicylic acid were used (5-ASA). To assess the clinical status, the Disease activity index scale was used, the population spectrum of leukocytes, CD3 + and CD45RA + lymphocytes, the concentration of IgG, IgM, IL-23 on the 3, 5 and 7 days of the experiment were determined.Results: In CD, the clinical signs of the disease progress from 3 to 7 days, the total number of leukocytes in the blood increases due to monocytes, lymphocytes, including CD3 +, CD45RA +, the concentration of IL-23, IgM, Ig G. Local use of turmeric extract in CD reduces the severity of clinical symptoms on days 5 and 7, restores the total number of leukocytes, lymphocytes, including CD3 +, the concentration of IgM on days 3, 5, 7, and IL-23 on days 5 and 7, partially restores serum concentration of IgG on the 3-rd, 5th, 7th day, IL-23—on the 3-rd day of observation. The eff ect of CD in the composition of rectal suppositories of turmeric extract is comparable to the eff ect of 5-ASA on the 3-rd, 5th, 7th day of observation in relation to the severity of clinical symptoms, the number of leukocytes, lymphocytes, CD3 + in the blood, the concentration of IgM and IgG; less pronounced in relation to the concentration of IL-23 on day 3.Conclusion. The clinical and immunological efficacy of local application of turmeric extract every 12 hours as part of the original rectal suppositories in experimental CD has been demonstrated, comparable with the use of rectal suppositories with 5-ASA.
Highlights
Local use of turmeric extract in Crohn’s disease (CD) reduces the severity of clinical symptoms on days 5 and 7, restores the total number of leukocytes, lymphocytes, including CD3 +, the concentration of IgM on days 3, 5, 7, and IL-23 on days 5 and 7, partially restores serum concentration of IgG on the 3-rd, 5th, 7th day, IL-23 — on the 3-rd day of observation
The effect of CD in the composition of rectal suppositories of turmeric extract is comparable to the effect of 5-aminosalicylic acid were used (5-ASA) on the 3-rd, 5th, 7th day of observation in relation to the severity of clinical symptoms, the number of leukocytes, lymphocytes, CD3 + in the blood, the concentration of IgM and IgG; less pronounced in relation to the concentration of IL-23 on day 3
Therapeutic roles of curcumin: lesson learned from clinical trials // AAPS J. 2013, vol 15, no. 1, pp. 195–218
Summary
The work was performed on 70 rats of the Wistar line. CD was unduced by the rectal administration of a trinitrobenzenesulfonic acid solution, rectal suppositories with 0.000075 mg of curcumin based on an alcohol solution of rhizome extract with turmeric roots were used after 12 hours for 7 days, in the comparison group rectal suppositories with 50 mg of 5-aminosalicylic acid were used (5-ASA). To assess the clinical status, the Disease activity index scale was used, the population spectrum of leukocytes, CD3 + and CD45RA + lymphocytes, the concentration of IgG, IgM, IL-23 on the 3, 5 and 7 days of the experiment were determined
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