Abstract
ALTHOUGH the problem of the surgically seeded wound and its relation to tumor recurrence had been recognized as early as 1885 by Gerster,9 and again in 1907 by Ryall,25 means to prevent seeding have consisted primarily of gown, glove, drape and instrument change. Occasionally, various wound washes have been used but without prior experimental basis or follow-up clinical reports. Within the past decade articles by Goligher,11 Cole5 and Smith,20 have re-emphasized this problem and have stimulated other experimental6, 10, 12, 13, 18, 27, 30 and clinical studies14, 28, 30 in search of tumoricidal agents which could be applied locally within the operative area This report describes the local effectiveness of proflavine hemisulfate (3–6-Diamino-acridinc hemisulfate) in preventing tumor takes in wounds artificially seeded with cells from two animal tumors. It also demonstrates several factors that can influence the tumoricidal effectiveness of this drug
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