Abstract
The effect of γ-aminobutyric acid (GABA) — superfused onto the surface of the ovary — on ovarian blood flow and on estradiol-17-β (E 2) and progesterone (P) secretion was studied in anaesthesized, pseudopregnant rats. GABA, 0.5 μmol per 50 μl per animal, significantly reduced the blood pressure in the femoral artery, increased ovarian blood flow, enhanced the rate of E 2 release and markedly decreased P secretion. The present findings indicate that local GABAergic mechanisms may be involved in the regulation of ovarian blood flow and hormone secretion.
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