Abstract
Single-molecule force spectroscopy with theoretical models such as Bell’s model has allowed for quantitative understanding of the kinetics of biomolecular bond rupture. Despite the ability of theoretical models to depict the kinetics of bond rupture and protein unfolding, these models usually do not take into account the effect of loading device. Here, we study the effect of loading device stiffness in the kinetics of biomolecular bond rupture by using a theoretical model that includes the effect of loading device stiffness. It is shown that the stiffness of loading device affects the kinetics of biomolecular bond rupture such that the stiffer loading device results in higher rupture force. Our study sheds light on the important role of loading device in biomolecular bond rupture mechanism.
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