Abstract
Rats were tested for changes in shock-elicited fighting (SEF) following the chronic administration of saline (IP); lithium (Li +) (20 mEq./l tap water) + saline (IP); desipramine (DMI) (15 mg/kg, IP); and DMI + Li + for 14 days. The repeated test trials indicated a significant decrease in SEF in Li +-saline group ( p<0.05), a significant increase ( p<p.05) in the DMI group, but no difference in the DMI + Li + group in comparison to saline controls. Combined treatment with DMI + Li + significantly reduced ( p<0.05) SEF in comparison to the DMI group. These results suggest that enhanced aggressivity resulting from chronic DMI administration and measured by SEF can be a useful behavioral model to study the action of lithium.
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