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Abstract
Abstract 1. Changes in noradrenaline uptake into synaptosomes prepared from various regions of rat brain were examined using a kinetic approach following treatment with and withdrawal from lithium. 2. A two-component uptake mechanism for noradrenaline was found in synaptosomes of control animals. 3. Lithium treatment enhanced noradrenaline uptake at low ligand concentrations, but abolished the high-capacity uptake mechanism. Lithium withdrawal returned uptake at low ligand concentrations to control values, but resulted in a “rebound” increase in the uptake due to the high-capacity system. 4. It is thought that these changes may be consequences of alterations in noradrenaline release following lithium treatment and withdrawal.
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