Abstract
The term of macrophage activation syndrome (MAS) refers to a condition caused by excessive activation and expansion of T lymphocytes and macrophagic histiocytes that exhibit hemophagocytic activity. The expansion of these cells also leads to a massive systemic inflammatory response associated with pan cytopenia, liver dysfunction, and coagulopathy consistent by disseminated intravascular coagulation (DIC). MAS has been reported in association with almost any rheumatic disease and most common in systemic onset JIA. However, the pathological mechanisms of MAS are not fully understood.
Highlights
The term of macrophage activation syndrome (MAS) refers to a condition caused by excessive activation and expansion of T lymphocytes and macrophagic histiocytes that exhibit hemophagocytic activity
Effect of listeriolysin O (LLO) secreted by listeria monocytogenes on apoptosis of macrophages derived from patients with macrophage activation syndrome- in vitro
The expansion of these cells leads to a massive systemic inflammatory response associated with pan cytopenia, liver dysfunction, and coagulopathy consistent by disseminated intravascular coagulation (DIC)
Summary
The term of macrophage activation syndrome (MAS) refers to a condition caused by excessive activation and expansion of T lymphocytes and macrophagic histiocytes that exhibit hemophagocytic activity. Effect of listeriolysin O (LLO) secreted by listeria monocytogenes on apoptosis of macrophages derived from patients with macrophage activation syndrome- in vitro From 21st European Pediatric Rheumatology (PReS) Congress Belgrade, Serbia. Introduction The term of macrophage activation syndrome (MAS) refers to a condition caused by excessive activation and expansion of T lymphocytes and macrophagic histiocytes that exhibit hemophagocytic activity.
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