Effect of Lippia alba essential oil administration on obesity and T2DM markers in Wistar rats

Maria Victoria Acevedo-Estupiñan,Fernando Rodríguez-Sanabria,Elena Stashenko

doi:10.15446/rcciquifa.v48n2.82718

Maria Victoria Acevedo-Estupiñan, Fernando Rodríguez-Sanabria + Show 1 more

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https://doi.org/10.15446/rcciquifa.v48n2.82718

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Abstract

Introduction: Lippia alba (Mill) N.E. Brown (Verbenaceae) is an aromatic plant from Central America, South America, and the Caribbean, it is traditionally used by the Colombian population to treat various diseases such as diabetes and hypertension. The purpose of this research was to evaluate the metabolic effects of Lippia alba essential oil (EO) oral administration on obesity and diabetes markers in Wistar rats. Methods: control and Streptozotocin (STZ) diabetes induced rats were used to evaluate the EO metabolic effects. Glucose and triglycerides were measured using commercial colorimetric kits, the animals’ weight was followed for 21 days treatment and TNF- and adiponectin concentration was determined with ELISA technique. Results: The consumption of EO shows body weight gain regulation, lower glucose and cholesterol levels in normal rats and lower TNF- in comparison with the Glibenclamide treated rats between the STZ diabetic groups. No toxic effects were founded. Conclusions: The EO exerts a benefical metabolic effect in rats, therefore it is interesting to be evaluate a future in human beings with T2DM or overweight.

Highlights

Throughout its existence, humans have faced hunger and diseases periods that have threatened with its extinction
The inflammatory response favors a catabolic state and suppresses anabolic pathways, such as the insulin signaling pathway [2]
Diabetes induction with STZ The oral glucose tolerance test performed on all work groups prior to initiating essential oil (EO) treatment did not show alterations in glucose uptake, figure 1, including the groups that were induced diabetes with STZ

Summary

Introduction

Throughout its existence, humans have faced hunger and diseases periods that have threatened with its extinction. Their survival has depended on the ability to store energy and use it in times of limited food availability as well as the ability to cope with infections and the damages caused by them. This is how the metabolic and immune systems have ensured the basic requirements for survival and have evolved together, independently. The inflammatory response (obesity is considered a state of chronic inflammation) favors a catabolic state and suppresses anabolic pathways, such as the insulin signaling pathway [2]

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