Abstract
BackgroundThis study aims to investigate the effect of lipid metabolism disorder on liver function in patients with malignant tumors after chemotherapy.MethodA total of 428 patients with malignant tumors with normal liver function in our hospital between May 2013 to June 2018 were divided into an observation group (lipid metabolism disorder, n = 265) and control group (normal lipid metabolism, n = 163). The lipid metabolism levels and liver damage of the two groups were compared before and after chemotherapy.ResultsNo significant differences in age, gender, body mass index, tumor types, history of surgery, levels of alanine aminotransferase (ALT; an indicator of liver function), and chemotherapy regimen were observed between the two groups. However, the observation group showed increased levels of total cholesterol (P = 0.000), triglycerides (P = 0.000), and low-density lipoprotein (P = 0.01), as well as decreased levels of high-density lipoprotein (P = 0.000) before chemotherapy compared with the control group. Furthermore, patients with lipid metabolism disorders were more likely to develop abnormal liver function after chemotherapy. Moreover, mixed lipid metabolism disorder was more likely to cause severe liver damage after chemotherapy. Additionally, the number of patients with lipid metabolism disorders after chemotherapy (n = 367) was significantly increased compared with before chemotherapy (n = 265) (P < 0.01), indicating that chemotherapy might induce or aggravate an abnormal lipid metabolism.ConclusionsAfter receiving chemotherapy, patients with malignant tumors presenting lipid metabolism disorders are more prone to liver damage and lipid metabolism disorders than patients with a normal lipid metabolism.
Highlights
This study aims to investigate the effect of lipid metabolism disorder on liver function in patients with malignant tumors after chemotherapy
We examined lipid metabolism in patients with malignant tumors who were treated at our hospital in recent years and assessed impairments in liver function after chemotherapy to investigate the effect of lipid metabolism disorders on liver function in patients undergoing chemotherapy
The observation group showed increased levels of total cholesterol (TC), TG, and LDL and decreased levels of HDL before chemotherapy A total of 428 patients with malignant tumors with normal liver function (199 males and 229 females, with an average age of 62.4 ± 9.2 years) were enrolled in our hospital from May 2013 to June 2018. These patients were divided into the lipid metabolism disorder group and normal lipid metabolism group according to the lipid metabolism status before chemotherapy
Summary
This study aims to investigate the effect of lipid metabolism disorder on liver function in patients with malignant tumors after chemotherapy. Malignant tumors are a serious threat to human health, and chemotherapy remains one of the main treatments. Chemotherapy has many toxic side effects [1]. As most chemotherapeutic drugs are metabolized by the liver, liver toxicity is one of the most common side effects [2]. Clinical manifestations of chemotherapy-induced liver damage are diverse, ranging from slight liver function abnormalities to severe cases of toxic hepatitis or fulminant hepatic failure. Hepatic toxicity is generally reversible [3], but may still cause fibrosis or cirrhosis if discontinued. Liver damage caused by chemotherapeutic drugs may lead to lipid metabolism disorders and even hyperlipidemia [4, 5]
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