Abstract
The aim of this study was to develop fluorescein sodium (NaFl) deformable liposomes with two different terpenes, d-limonene and 1,8 cineole, as skin penetration enhancer. NaFl was used as the model drug as it is a hydrophilic diagnostic agent, and has low skin penetration. The liposomes were prepared by reverse phase evaporation method. Their particle size, surface charge, and shape were characterized, in vitro skin penetration of NaFl through porcine skin were investigated. The obtained deformable liposomes were small particle size (<100 nm), negative charge and spherical shape. The liposome containing d-limonene provided the highest amount of NaFl followed by deformable liposomes with 1,8 cineole and conventional liposomes, repectively. The enhancement ratio of formulations containing terpenes were about 18-38fold compared with the conventional liposomes. These results indicated that the obtained deformable liposomes could be used as transdermal delivery of NaFl and incorporation of terpenes into deformable liposomes provided high efficiency for NaFl delivery through the skin.
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