Effect of lifestyle interventions on oxidative stress in elderly hypertensive and in normal individuals

Abstract

Introduction: Oxidative stress has emerged as one of the important factors of aging as well as various diseases including hypertension. A Few changes in lifestyle like food habits and exercise leads to significant decrease in the oxidative stress and inflammation which in turn improves the endothelium functions. Aim: The present study was designed to assess and compare the effect of lifestyle modifications on oxidative stress in elderly essential hypertensive patients as well as in normotensive elderly subjects. Materials and Methods: One hundred four normotensive elderly subjects of group I and one hundred eighty-six elderly hypertensive patients of group II between 60 to 80 years of age successfully completed three months lifestyle modifications program conducted in the department of physiology, Santosh Medical College Ghaziabad. Oxidative stress markers GSH, SOD, MDA and blood pressure were measured before and after lifestyle modification program. Results: The findings of the present study showed that SBP (p<0.001), DBP (p<0.001), MAP (p<0.001) were significantly low in group II hypertensive patients in comparison of group I normotensive subjects. Value of SOD increased significantly in group II hypertensive patients in comparison to group I normotensive subjects.