Effect of lidocaine carbonate and intravenous flurbiprofen axetil intrapelvic on irrigation and incision infiltration for postoperative pain after gynecological laparoscopy

Abstract

Objective To compare the analgesia effect of lidocaine carbonate combined with intravenous flurbiprofen axetil with intravenous flurbiprofen axetil on intrapelvic irrigation and incision infiltration after gynecological laparoscopy. Methods Seventy-five patients scheduled for gynecological laparoscopy under general anesthesia were divided into 3 groups by random number table method with 25 cases each. Patients in control group 1 received intravenous flurbiprofen axetil 100 mg after surgery; patients in control group 2 received intrapelvic irrigation with 0.35% lidocaine carbonate 100 ml, and incision infiltration with 0.87% lidocaine carbonate 10 ml respectively after surgery; patients in observation group received the combination of control group 1 and control group 2. The visual analogue scores (VAS) at 1, 4, 8, 12 and 24 h after surgery, time of passage of gas by anus and untoward reaction were recorded. Results One case in control group 1 and 1 case in observation group withdrew from the study. The VAS at 1, 4, 8, 12 and 24 h in observation group were (9.5±7.9), (14.9±8.7), (17.2±10.3), (12.2±7.7), (5.3±3.8) mm, in control group 1 were (39.2±15.0), (33.4±13.0), (36.2±12.8), (35.8±12.7), (10.6±4.2) mm, and in control group 2 were (26.6±13.0), (30.2±12.0), (33.3±13.1), (30.4±9.8), (9.8±4.7) mm. And there were statistical differences between observation group and control group 1, 2 (P 0.05). Conclusion Intrapelvic irrigation and incision infiltration with lidocaine carbonate and intravenous flurbiprofen axetil compared with intravenous flurbiprofen axetil alone after gynecological laparoscopy can significantly reduce the pain intensity and analgesia requirement, without increasing the untoward reaction incidence. Key words: Lidocaine; Flurbiprofen; Analgesia; Laparoscopy