Abstract
In the present study an innovative attempt was made using Leukotriene B4 (LTB4) and Oyster glycogen (OG), non-specific immunomodulators, for the treatment of subclinical endometritis (SCE) in repeat breeding crossbred cows. Thirty six subclinical endometritis repeat breeding cows were randomly divided into 3 equal groups (G-I, G-II and G-III). The cows in treatment groups G-I and G-II received single intrauterine (iu) infusion with 50 ml of 30 nmol/L LTB4 and 10 mg/ml OG, respectively, whereas the cows in G-III served as control. Blood samples collected just before treatment (0 hr), 24 hr post-treatment and at subsequent estrus were assayed for total leukocyte count (TLC), lipid peroxide (LPO) and nitric oxide (NO). Following treatment the recovery rate was assessed at subsequent estrus by determining the pH of cervico-vaginal mucus (CVM), white side test and percentage of polymorphonuclear (PMN) cells in uterine cytology. The recovery rate in G-I (83.3%) and G-II (75.0%) was greater (P
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